Phenotypically similar AMLs are rapidly generated from MYC-transduced CD34⁺ 38⁻ and GMP CB cells. (A) Experimental design. (B) Survival of mice transplanted with MYC-transduced CD34⁺38⁻ (i, red) or GMP (ii, blue) CB cells (solid, primary transplants; dotted, secondary transplants). (C) Percent of GFP⁺ (MYC⁺) cells positive for the indicated surface markers in primary AMLs produced from MYC-transduced CD34⁺38⁻ cells (n = 2) or GMPs (n = 2) or secondary AMLs originally initiated from MYC-transduced CD34⁺38⁻ cells (n = 3), all in NRG-3GS recipients.