MDS and sAML harboring mutTP53 are characterized by immune checkpoint overexpression at the stem cell level, as well as a reduced number of cytotoxic T cells and expansion of MDSCs and ICOShigh/PD-1neg Tregs. HSC, hematopoietic stem cell.
MDS and sAML harboring mutTP53 are characterized by immune checkpoint overexpression at the stem cell level, as well as a reduced number of cytotoxic T cells and expansion of MDSCs and ICOShigh/PD-1neg Tregs. HSC, hematopoietic stem cell.