BH3 mimetic profiling to dissect venetoclax resistance. CLL cells were cultured on 3T3 or 3T40L for 24 hours. After detachment, cells were treated with the indicated BH3 mimetics for an additional 24 hours. The respective drug concentrations were determined in preliminary experiments. Viability was measured by flow cytometry using DiOC6/TO-PRO-3 staining. Summary of viability data for CD40-stimulated CLL cells treated with BH3 mimetics (n = 16) (A-D) or with low-dose BH3 mimetics (n = 5) (E). (F) Table showing synergy indexes of BH3 mimetics in combination treatments (n = 16).