FcγRIIA accelerates SLE development in the B/WF1.FcγRIIA^TGNmouse model. Survival analysis of female (n = 49) (A) and male (n = 33) (B) B/WF1.FcγRIIA^Null and B/WF1.FcγRIIA^TGN mice. (C) Evolution of urine albumin in female B/WF1.FcγRIIA^Null and B/WF1.FcγRIIA^TGN mice aged 10 to 32 weeks; n = 5 to 8 per group. (D) Kidney histology, hematoxylin and eosin staining of female B/WF1.FcγRIIA^Null and B/WF1.FcγRIIA^TGN kidneys at 28 weeks. Representative images of n = 5 per group. Original magnification ×100. Histological assessment of: extracapillary and endocapillary glomerulonephritis (GN) (E), interstitial inflammation (F), kidney tubular dilatation (G), and epithelial atrophy (H) in female B/WF1.FcγRIIA^TGN mice (n = 6) and their age-matched B/WF1.FcγRIIA^Null littermates (n = 5). (I-K) Analysis of IgG distribution in the kidneys according to electron microscopy. (L) Quantification of serum IFN-α in female B/WF1.FcγRIIA^TGN mice and their age-matched B/WF1.FcγRIIA^Null littermates (n = 4-5). Data are presented as the mean ± SEM (C,L), or mean with median (E-I). Statistical analyses: log-rank survival analysis (A-B), 2-way analysis of variance, Šídák’s multiple comparisons test (C), unpaired Student t test (E-K), and Mann-Whitney U test (L). *P < .05, **P < .01. P = .05 are indicated.