A general overview of my approach is shown. A first step is to assess patient medical comorbidities because this influences the risks and benefits of imatinib vs specific second-generation tyrosine kinase inhibitors (TKIs). (A) Patients without comorbidities. (B) Patients with particular comorbidities. Because comorbidities, in particular cardiovascular comorbidities, increase with age, selecting a second-generation TKI in older individuals with or without comorbidities requires a careful discussion and monitoring. Patient goals and preferences are also important and influence decision making.