Genomic-based treatment algorithm for symptomatic treatment-naive patients with WM. Benda-R, bendamustine and rituximab; BTK-I, Bruton tyrosine kinase inhibitor; CAGG, cold agglutinin disease; CRYOS, cryoglobulins; DRC, dexamethasone, rituximab, cyclophosphamide; HV, hyperviscosity; PI, proteasome inhibitor; PN, progressive neuropathy. Adapted with permission from Treon et al.⁴⁹