Genomic-based treatment algorithm for symptomatic, previously treated, or refractory patients with WM. Benda-R, bendamustine and rituximab; BTK-I, BTK inhibitor; CAGG, cold agglutinin disease; CRYOS, cryoglobulins; DRC, dexamethasone, rituximab, cyclophosphamide; HV, hyperviscosity; NA, nucleoside analogs; PI, proteasome inhibitor; PN, progressive neuropathy. Adapted with permission from Treon et al.⁴⁹