Figure 1.
![Impact of NPM1mut TL log10 reduction on CIR after 2 induction cycles. Significantly fewer relapses occurred in patients achieving a ≥3-log10 reduction (blue curve) in NPM1mut TLs than in patients with a log10 reduction < 3 (red curve) in BM (A) (4-year CIR rate, 28.5%; 95% confidence interval [CI], 22.6%-34.4% vs 60%; 95% CI, 43.5%-76.4%; P < .0001) and PB (B) (4-year CIR rate, 33.9%; 95% CI, 27.7%-40.1% vs 62.5%; 95% CI, 38.4%-86.6%; P = .01). Shaded area represents 95% CI.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/136/26/10.1182_blood.2020005998/1/bloodbld2020005998f1.png?Expires=1735861727&Signature=3ygklCJCOTMzJd2Ys-YtJZYIZVVl5Gk-OAoNBfeTq4uefdr2fCR6pFXePO3Cxp9tWdOL-0nGS6GiOq9z~Z7YEJX9oUgSnjQaS9SP4H6qzgmu~FvngAvKuPfmM0nd1r8h01M1hPjYZ1lvtYXu~YZ5BXoWrY9yMZiNLbkSpSISI6OeLbl4m7A3WbzCIA1KijOdzoU4y6oDibi1765EaUP0JxA~BsnXwnz5LVQoRblURPB~AzwriloitklP6sv7kKrIeiaaNfXDFbO1Xp-8PjhbzTWmvGz4JyIfW3IItIowLZ5w8B6RD1aUydXR4UZji9GA0Nlvt999gBcg2e-~w44~Ig__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Impact of NPM1mut TL log10 reduction on CIR after 2 induction cycles. Significantly fewer relapses occurred in patients achieving a ≥3-log10 reduction (blue curve) in NPM1mut TLs than in patients with a log10 reduction < 3 (red curve) in BM (A) (4-year CIR rate, 28.5%; 95% confidence interval [CI], 22.6%-34.4% vs 60%; 95% CI, 43.5%-76.4%; P < .0001) and PB (B) (4-year CIR rate, 33.9%; 95% CI, 27.7%-40.1% vs 62.5%; 95% CI, 38.4%-86.6%; P = .01). Shaded area represents 95% CI.