Association of telomere length with age and somatic mutations. (A) Association between recipient telomere length and age at transplantation. Linear regression lines for age groups 0 to 10, 10 to 40, and 40 to 77 years are shown in orange. Red and blue areas highlight the telomere lengths in the shortest quartile and the longest telomere length groups, respectively. (B) Violin plots for distribution of age at transplantation in telomere length groups in patients age 40 or older. Yellow lines indicate median ages at transplantation. (C) Distribution of telomere lengths according to somatic gene mutations in patients age 40 or older. Yellow lines represent the median telomere lengths and genes are ordered from shortest to longest by median telomere length. Areas in red and blue reflect telomere lengths in the shortest and the longest quartile telomere length groups, respectively. Genes with more than 15 mutated patients shown. (D) Association between somatic mutations and the shortest or the longest quartile telomere length groups in patients age 40 years or older. The x-axis depicts the magnitude of association (log₂ odds ratio), and the y-axis shows the negative log of the nominal P value (-log₁₀P). The dashed line represents the threshold of significance (.05) for nominal P values. Each circle represents a mutated gene and the size of the circle reflects the number of patients with mutation. Genes with a mutation in at least 10 patients are shown.