Global hematological response to mavorixafor. (A) Mean dose response ANC-time profile. The ANC threshold (500 neutrophils per microliter) is indicated by the dashed line. (B) Mean dose response ALC-time profile. The ALC threshold (1000 cells per microliter) is indicated by the dashed line. (C) Increasing concentrations of mavorixafor result in an increase in the total WBC counts in patients with WHIM syndrome. Box plots show WBC change from baseline ratio at 4 hours for 300-mg and 400-mg once-daily mavorixafor. For box plots, the dashed line is the median; the solid line is the arithmetic mean; the lower and upper ends of the boxes are the 25th and 75th percentiles, respectively; the lower whiskers show the lowest data value still within 1.5 interquartile range (IQR) of the lower quartile, and the upper whiskers show the highest value still within 1.5 IQR of the upper quartile. (D) Box plots of AUC_ANC for mavorixafor doses up to 400 mg, once daily. Box plots show AUC_ANC >600 cells per microliter threshold over 24 hours. The dotted line represents a null net AUC relative to the ANC theshold of 600 neutrophils/μL. The values above the dotted line represents the net AUC result above this threshold of 600 neutrophils/μL. N, number of patients; QD, once daily.