Figure 7.
Effects of bromodomain inhibitors on VAV1-mutant tumor cells. (A) Schematic showing protocol used for vehicle or JQ1 treatment. Single-cell suspensions were prepared from spleens of nude mice transplanted with T-LBL or Lym from p53−/−VAV1-Tg mice or T-LBL from p53−/− mice and intraperitoneally injected into nude mice. JQ1 at 3 mg/kg was injected intraperitoneally into secondarily transplanted nude mice once every 2 days from day 7 until animals died. (B-D) Survival curves for vehicle- and JQ1-treated nude mice transplanted with T-LBL from p53−/−VAV1-Tg mice (B), Lym from p53−/−VAV1-Tg mice (C), or T-LBL from p53−/− mice (D).

Effects of bromodomain inhibitors on VAV1-mutant tumor cells. (A) Schematic showing protocol used for vehicle or JQ1 treatment. Single-cell suspensions were prepared from spleens of nude mice transplanted with T-LBL or Lym from p53−/−VAV1-Tg mice or T-LBL from p53−/− mice and intraperitoneally injected into nude mice. JQ1 at 3 mg/kg was injected intraperitoneally into secondarily transplanted nude mice once every 2 days from day 7 until animals died. (B-D) Survival curves for vehicle- and JQ1-treated nude mice transplanted with T-LBL from p53−/−VAV1-Tg mice (B), Lym from p53−/−VAV1-Tg mice (C), or T-LBL from p53−/− mice (D).

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