Forest plots for PFS and OS for available markers. The percentage (%) of patients per risk group, the hazard ratios relative to the lowest-risk groups, Pzph (a global P value indicating deviation from the proportional hazards assumption), and Plogrank (log-rank P value) are shown for each marker. The forest plots show the hazard ratios for PFS (A) and OS (B) with corresponding 95% confidence interval as whiskers. For HR FISH, the combination of FISH markers within the R-ISS definition is used. ULN, upper limit of normal.