Spectrum of clonal hematopoiesis for individuals with erythrocytosis with and without concurrent leuko- and/or thrombocytosis. (A) Mutational landscape for all somatic mutations detected in sequenced individuals with erythrocytosis (n = 133). (B) Proportion of individuals with 1 or more mutations according to the presence of concurrent leuko- and/or thrombocytosis. (C) Proportion of individuals with mutated JAK2, BCOR/BCORL1, or other mutations (including CHIP genes) according to the presence of concurrent leuko- and/or thrombocytosis. (D) Contribution of individual mutated genes to the spectrum of clonal hematopoiesis detected in individuals with isolated erythrocytosis (red) and individuals with erythrocytosis with concurrent leuko- and/or thrombocytosis (blue). Bars indicate the proportion of individuals with a gene mutation.