Mutational and cytogenetic landscape of 350 CBF-AML patients. Genes are grouped into functional groups. Each column represents a single patient; each colored box indicates a specified driver mutation. Wild-type cases are illustrated in light gray, missense mutations in blue, indels in purple, nonsense mutations in green, splice site mutations in pink, and additional chromosomal aberrations (ACA) in dark gray. Bar plots indicate the relative frequency of all aberrations in the corresponding CBF-AML cohort. CH, chromatin; CO, cohesin; ME, methylation; OT, other; SI, RTK/RAS signaling; TR, transcription.