Binding of ciraparantag to 4 anticoagulants, based on DLS data. Migration of curves to the right indicates physical association between ciraparantag (CIRA) and the anticoagulants dabigatran (A; DABI), apixaban (B), edoxaban (C; EDOX), and rivaroxaban (D; RIVA). (See supplemental Figure 1 for data on UFH and enoxaparin.) In the rivaroxaban graph, the 2 CIRA:RIVA concentrations are superimposed but only 1 curve is shown.