Nonbinding of ciraparantag to various drugs, coagulation factors, or blood components, as determined by DLS. Thrombin (A), factor Xa (B), diltiazem (C; DILT), and digoxin (D; DIGO). Target proteins (eg, thrombin), with or without ciraparantag (CIRA), migrated to the same position, reflecting the presence of the larger target protein, regardless of the presence of ciraparantag. Based on migration, there was no evidence of a larger mass as would be present if ciraparantag had bound to the target. (See supplemental Figure 2 for additional drugs tested.)