Effect of ciraparantag in reversing edoxaban anticoagulation and other anticoagulants. (A) Blood loss after oral edoxaban (10 mg/kg) with increasing doses of ciraparantag. (B) Blood loss during specific collection periods after edoxaban (10 mg/kg) and ciraparantag (30 mg/kg). (C) Blood loss when ciraparantag was administered after rat tail transection (edoxaban 10 mg/kg; ciraparantag 30 mg/kg). (D) Blood loss after oral dabigatran (37.5 mg/kg). (E) Blood loss after oral apixaban (3.125 mg/kg). (F) Blood loss after oral rivaroxaban (5 mg/kg). (G) Blood loss after 1 mg/kg IV UFH compared with 10 mg/kg protamine. (H) Blood loss after 10 mg/kg IV enoxaparin compared with 10 mg/kg protamine. *P < .05; **P < .01; ***P < .001.