Hoxa9-binding sites in Trib1 hi and null cells show close association with enhancers and C/EBPα-binding sites. (A) Global distribution of Hoxa9-binding peaks. (B) MEME suite motif analysis shows enrichment of the C/EBPα motif in Hoxa9-binding peaks and vice versa in Trib1 null cells. The Meis1-binding motif was also enriched in both Hoxa9 and C/EBPα peaks. (C) Venn diagram showing frequent overlaps between Hoxa9- and C/EBPα-binding peaks in Trib1 null cells (left). Density plot of Hoxa9 and C/EBPα ChIP-seq data sets centered on TSSs (right). Each row represents a single peak. (D) Meta-profile of average ChIP-seq signals for Hoxa9 and H3K27ac in Trib1 null (left) and hi (right) cells in the region ± 5 kb around TSSs. (E) ChIP-seq occupancy profiles for C/EBPα, Hoxa9, and H3K27ac at the Chek1, Selp, and Ly6e loci.