Genomic landscape of diagnostic and MRD tumor cells in standard- vs high-risk MM. Number and frequency of shared vs private mutations (A) and CNA (B) in paired diagnostic and MRD tumor cells are indicated in Venn diagrams (n = 14). Oncoprint of genomic mutations (single-nucleotide variants [SNVs] and insertions/deletions) (C) and CNA and loss of heterozygosity (LOH) (D) in patients with standard- and high-risk (both n = 7) CAs. Genes are distributed in rows, and columns represent paired diagnostic and MRD tumor cells of each patient. Two-dimensional density plots showing tumor cell clustering according to mutations (E) and CNAs (F) detectable in paired diagnostic and MRD tumor cells (x- and y-axis, respectively). Private events at diagnosis are highlighted in green and at MRD stages in red; persistent events are in orange. Stacked plots represent the percentage of tumor cells showing private and persistent genetic events. CCF, cancer-cell fraction.