CDK6-dependent transcriptomic alterations. (A) Volcano plots summarizing CDK6-mediated differential gene expression between untransformed (left) and BCR/ABL^p210 (right) HPC^LSKs. Each dot represents a unique gene; red dots indicate statistically significant deregulated genes (FDR < 0.05 and FC ± 1.5). FC, fold change; FDR, false discovery rate. (B) Venn diagrams showing overlaps between upregulated genes (upper) or downregulated genes (lower) in untransformed HPC^LSKsCdk6^−/− and Cdk6^−/− BCR/ABL^p210 HPC^LSKs compared with controls. (C) GO enrichment analyses of CDK6 regulated genes in untransformed (left) and BCR/ABL^p210 (middle) HPC^LSKs and of commonly CDK6 regulated genes in these cell types (right). (D) Heatmaps summarizing expression of 101 genes, which are commonly regulated in a CDK6-dependent manner in murine and human BCR/ABL^p210 cells. Each row represents a unique gene, and each column represents a unique sample. Colors range from blue (low expression) to red (high expression). Results from GO enrichment analyses of these genes are shown in the bar chart (right). diff., differentiation; neg., negative; pos., positive; reg., regulation.