Platelet count monitoring in a patient with CTP during and after eltrombopag. Dots represent actual platelet count measurements; the broken line indicates expected platelet count cycling estimated by fitting sine wave to the data. During eltrombopag therapy, the platelet count seemingly increased, but nevertheless, severe thrombocytopenia was seen at 1 occasion 3 weeks after eltrombopag initiation. After discontinuation of eltrombopag, thrombocytosis subsided, and platelet count cycling with a nadir and zenith approximately every 25 days, respectively, became obvious.