Neutrophils from patients with GPS show lower SG protein abundance compared with healthy control neutrophils (PMNs). (A) Volcano plot comparing PMN proteomes of patients with GPS vs healthy controls (HC). (B) Label-free intensity values of PMN of patients with GPS vs HCs. The white and red circles indicate patients 1, 7, and 8 in supplemental Figure 3, respectively. (C) GO term enrichment analysis of proteins with decreased abundancies in PMNs of patients with GPS. (D) Distribution of granule-annotated proteins with decreased abundancies in PMNs of patients with and corresponding granule protein enrichment analysis. BP, biological process; CC, cellular component.; CM, cell membrane; FG, ficolin-1-rich granule; LFQ, label free quantification; SV, secretory vesicle.