Time course of treatment of CRS-associated coagulopathy on patients treated with tisagenlecleucel. Patient 1 (A), patient 2 (B), patient 3 (C). Days after tisagenlecleucel infusion; day 1, infusion day. Arrows, the day of blood product replacement with fibrinogen concentrate; orange triangles, CRS onset by grade; blue triangles, CRS resolution. ALL, acute lymphoblastic leukemia; Gr, grade; ICU, intensive care unit; s/p, status post; SCT, stem cell transplantation.