Guidelines for use of replacement to treat CRS-associated hypofibrinogenemia or coagulopathy. Fibrinogen concentrate (A), cryoprecipitate (B). *Minor bleeding events include epistaxis, intramuscular bleeding, and menorrhagia. †From RiaSTAP Prescribing Information.¹³  ‡Major bleeding events include head trauma and intracranial hemorrhage. For patients without bleeding, fibrinogen levels should be monitored and maintained at >1.5 g/L. §Each unit of cryoprecipitate contains at least 150 mg fibrinogen per unit. Two units of cryoprecipitate per 10 kg body weight generally increases fibrinogen concentration by 1 g/L, except in cases of DIC or continued bleeding with massive transfusion.