Figure 1.
Nanogel synthesis schematic and characterization. (A) Schematic of core-shell particle synthesis and FSN fabrication followed by subsequent tPA loading through a rehydration technique. (B) Core, core-shell, FSN, tPA-FSN, and tPA-CS-IgG size characterization hydrodynamic measurements using 108 particles. (C) SEM (JEOL JSM-7600F) images are shown at a magnification of 80 000× to validate core-shell architecture and FSN and tPA-FSN structure. Representative AFM (Asylum Research MFP-3D) dry images using 30 particles (D) and representative height traces using 30 particles (E). (F) Quantification of antibody molecules per particle for FSN and CS-IgG particles. Data are presented as average ± standard deviation.

Nanogel synthesis schematic and characterization. (A) Schematic of core-shell particle synthesis and FSN fabrication followed by subsequent tPA loading through a rehydration technique. (B) Core, core-shell, FSN, tPA-FSN, and tPA-CS-IgG size characterization hydrodynamic measurements using 108 particles. (C) SEM (JEOL JSM-7600F) images are shown at a magnification of 80 000× to validate core-shell architecture and FSN and tPA-FSN structure. Representative AFM (Asylum Research MFP-3D) dry images using 30 particles (D) and representative height traces using 30 particles (E). (F) Quantification of antibody molecules per particle for FSN and CS-IgG particles. Data are presented as average ± standard deviation.

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