Thrombosis is accelerated and hemostasis improved in EXOC3 KO mice. (A) Anesthetized mice were infused with Dylight-488–conjugated anti-GPIbβ antibody before ferric chloride–mediated injury of the carotid artery up to a 15-minute experimental end point. Displayed are representative images of thrombus formation (i), with median fluorescence intensity values plotted over time (ii) and total median fluorescence intensity values compared at 7.5- and 15-minute time points (iii). (B) For tail bleeding analysis, anesthetized mice had tails excised 5 mm from the tip before immersion in 37°C saline, and total bleed time was monitored over a 10-minute experimental end point. Data are presented as the mean ± standard error of the mean. n = 7 for WT mice and n = 9 for KO mice (A); n = 10 (B). *P < .05 vs indicated sample. AU, arbitrary units.