Outcomes according to 10-day angiopoietin-2 and IL-6 course. Length of hospitalization according to 10-day angiopoietin-2 (A) and IL-6 (B) courses. PaO₂/FiO₂ ratio levels at 1 month according to 10-day angopoietin-2 (C) and IL-6 (D) courses. Cumulative incidence of nonresolving pulmonary condition according to 10-day angiopoietin-2 course in derivation (E) and validation (F) cohorts. Cumulative incidence of nonresolving pulmonary condition according to 10-day IL-6 course in derivation (G) and validation (H) cohorts. Red line, increase of at least twofold from baseline; blue line, no increase.