Changes in B cells following activation of NF-κB pathways. (A) Representative histograms of the percentage of B220⁺ cells in the spleens of mice with the classical (Class.), alternative (Alt.), or both NF-κB pathways (DPWY) constitutively activated under the control of mb1 cre compared with LMC. (B) Summary data of the proportion of B cells in the spleen. (C) Summary data of the number of B cells in the spleen. Data for A-C are from n = 8-17 mice per group, from 3-5 independent experiments; summary data are shown as the mean ± standard error of the mean (SEM). ***P < .001.