Event timeline of the study cohort. The time from diagnosis to longitudinal events for each patient is shown. Cases are depicted from top to bottom, grouped based on age at onset. Stars indicate occurrence of an allogeneic HSCT. Samples included in the current study as well as the next-generation sequencing method applied are indicated by filled circles (WGS, 90×), open circles (WGS, 30×), and diamonds (WES). Patients in remission at the latest follow-up are indicated with an ellipsis at the end of the respective bar. R1/2/3/4, sequential relapses; HSCT, hematopoietic stem cell transplantation.