Changes in VAF in longitudinal patient-matched AML samples. (A-B): Distribution of nonsynonymous SNVs and small indels among representative patient-matched longitudinal AML samples from 3 adult (A) and 3 pediatric (B) cases. (C) Changes in VAF between patient-matched diagnosis and R/PR samples for GATA2, NRAS, and WT1. Detailed information regarding samples used for generating this figure is present in supplemental Table 12G. Additional graphs with recurrently altered genes as well as all adult and pediatric patient-matched longitudinal diagnostic and R/PR samples are presented in supplemental Figures 6-8. D, diagnosis; VAF, variant allele frequency.