Co-occurrence and mutual exclusion of mutations in recurrently altered genes in relapsing AML. Co-occurrence and mutual exclusion of mutations in adults at diagnosis (A) and relapse (B), and in children at diagnosis (C) and relapse (D). Significance was calculated using a pairwise Fisher’s exact test. •P < .1; *P < .05. The odds ratio (OR) gives directionality, with OR >1 indicating co-occurrence (green) and OR <1 indicating mutual exclusion (brown). The number of mutated cases for each gene is shown in brackets. Detailed information regarding samples used for generating this figure is presented in supplemental Table 12H.