Combination therapy using BCL inhibitor and AraC. (A) Schematic illustration of serial BM transplantation (BMT) assay. (B) Primary AML cells were transplanted in recipient mice and treated with AraC (10 mg/kg), BPI (25 mg/ kg), or in combination for 3 weeks after confirming engraftment. Percent human AML cells in each arm was compared. (C) BM cells were harvested and transplanted into new recipient mice (secondary transplant). NS, not significant; PDX, patient-derived xenograft.