Response stratified by TET2 and ASXL1 genotype. Comparison of overall response rate (A) and complete remission rate (B) among combinations of TET2 and ASXL1 genotypes (TET2-mutated [mut]/ASXL1-wt [wild-type], n = 29; TET2-wt/ASXL1-wt, n = 159; ASXL1-mut, n = 47). The vertical axis represents the frequency of response and comparisons between specific groups are annotated. *Denotes statistical significance (P < .05).