OS in CAVALLI vs GOYA IPI 2-5. Kaplan-Meier curvesfor the overall population (A) and the Bcl-2 IHC⁺ (B), Bcl-2 IHC⁻ (C), and DEL (D) subgroups. The following covariates were adjusted: age, sex, ECOG PS, bone marrow involvement, IPI (high vs nonhigh), bulky disease (>7.5 cm), disease stage (IV vs I-III), LDH, and COO.