The impact of CsA and Q-VD-OPh on antibody-mediated procoagulant platelets. (A-B) CsA and Q-VD-OPh inhibition of COVID-19–induced ΔΨ depolarization (A) and PS externalization (B). (C-D) CsA significantly inhibits the depolarization of ΔΨm and PS expression in COVID-19–positive patients. Q-VD-OPh was not able to inhibit ΔΨm depolarization (C) but significantly reduced PS externalization (D). Data are presented as mean ± SEM of the measured FI compared with control. Not significant, *P < .05, **P < .01, ***P < .001, ****P < .0001. The number of sera tested is reported in each graphic.