Safety profile. (A) Hematology analysis by Hemavet, using blood samples collected 16 weeks after transduction. Data are means with SD representing 9 mice transduced with HDAd-ABE-sgHBG-2 and 3 nontransduced naive mice (Nontr). (B) Percentage of reticulocytes in blood samples at week 16. The blood smears were stained with Brilliant cresyl blue. (C) Cellular composition of bone marrow mononuclear cells at the terminal point of primary mice. Nontransduced mice were used as the control. Each symbol represents 1 animal. The differences between the groups were not significant.