Figure 6.
XBP1 splicing defects are conserved in human HL-60 cells with mutant SRP54 expression. (A) ΔCT values for XBP1s expression of DMSO-treated SRP54 (WT) transduced HL-60 cells compared with SRP54 (G226E) transduced HL-60 cells measured by qRT-PCR. (B) ΔCT values for XBP1s for Tm-treated SRP54 (WT) compared with SRP54 (G226E) transduced HL-60 cells measured by qRT-PCR. (C) Fold change of XBP1s expression upon Tm treatment compared with DMSO treatment of SRP54 (WT) and SRP54 (G226E) transduced HL-60 cells. We used 3 biological replicates. Student t test was used for statistical analysis. ***P < .005; ****P < .0001. Bar plots represent the mean value of the replicates. Error bars indicate the standard deviation of the mean.

XBP1 splicing defects are conserved in human HL-60 cells with mutant SRP54 expression. (A) ΔCT values for XBP1s expression of DMSO-treated SRP54 (WT) transduced HL-60 cells compared with SRP54 (G226E) transduced HL-60 cells measured by qRT-PCR. (B) ΔCT values for XBP1s for Tm-treated SRP54 (WT) compared with SRP54 (G226E) transduced HL-60 cells measured by qRT-PCR. (C) Fold change of XBP1s expression upon Tm treatment compared with DMSO treatment of SRP54 (WT) and SRP54 (G226E) transduced HL-60 cells. We used 3 biological replicates. Student t test was used for statistical analysis. ***P < .005; ****P < .0001. Bar plots represent the mean value of the replicates. Error bars indicate the standard deviation of the mean.

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