Figure 2.
Histopathological images. (A) A case with weak staining of IL-6+ leukocytes (red arrowheads), and negative HRS cells (black arrow). (B) Example of a case with a high frequency of IL-6+ leukocytes (red arrow). No HRS cells in this image. (C) A case with several IL-6+ HRS cells (red arrowheads). (A-C) Immunohistochemical staining with IL-6 antibody; original magnification ×400. (D) Histogram for IL-6 scoring distribution for positive leukocytes. X-axis proportions of cells stained positive for IL-6 antibody in the TME of cHL. Y-axis, Frequency of patients. *The first bar is cropped for illustrative purposes. (E) The same as for panel D but for HRS cells. Histograms in panels D and E show a nonnormal distribution: the Shapiro-Wilk normality test (P = .001).

Histopathological images. (A) A case with weak staining of IL-6+ leukocytes (red arrowheads), and negative HRS cells (black arrow). (B) Example of a case with a high frequency of IL-6+ leukocytes (red arrow). No HRS cells in this image. (C) A case with several IL-6+ HRS cells (red arrowheads). (A-C) Immunohistochemical staining with IL-6 antibody; original magnification ×400. (D) Histogram for IL-6 scoring distribution for positive leukocytes. X-axis proportions of cells stained positive for IL-6 antibody in the TME of cHL. Y-axis, Frequency of patients. *The first bar is cropped for illustrative purposes. (E) The same as for panel D but for HRS cells. Histograms in panels D and E show a nonnormal distribution: the Shapiro-Wilk normality test (P = .001).

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