Comparison of mutations identified in BM, cfDNA, and xenograft samples. (A) Number of mutations identified in BM, cfDNA, and xenograft samples. Box-and-whisker plots show the boxes indicating median and interquartile range, and the whiskers denoting the range. The overlaid points are the observed mutation burden of individual samples. (B) Median VAFs of mutations identified in BM, cfDNA, and xenograft samples. Box-and-whisker plots show the boxes indicating median and interquartile range, and the whiskers denoting the range. The overlaid points are the observed mutation burden of individual samples. Asterisks indicate significant differences (Mann-Whitney U test). (C) VAFs of mutations detected in cfDNA and BM cells of IVL_03 and IVL_22 are plotted. VAFs are calculated using the allelic counts of amplicon sequencing (IVL_03) and WES (IVL_22). (D) Mutations identified in BM and cfDNA samples in IVL_03 and IVL_22 are shown. Unique mutations and shared mutations between the 2 samples are shown in different colors.