Landscape of genetic alterations in IVLBCL. (A) Driver mutations and CNAs detected in 21 patients with IVLBCL are shown. The vertical line indicates 1 patient. (B) Genes frequently affected by SHMs identified in IVLBCL. (C) Comparison of the frequency of driver mutations among IVLBCL, PCNSL, ABC-type DLBCL, and germinal center B-cell (GCB)-type DLBCL. Asterisks indicate genes that are significantly more frequently mutated in IVLBCL compared with ABC-type DLBCL (Fisher exact test).