Avadomide effects signaling pathways and immune cell infiltration in DLBCL tumors. (A) RNA sequencing with immune cell deconvolution performed on screening and on-treatment (C1D10/15) biopsy specimens, showing enrichment/depletion relative to screening biopsy. (B) Cellular composition in paired tumor biopsy specimens by immunohistochemistry. Original magnification, ×20. (C) Intratumoral cell counts in screening vs on-treatment biopsy specimens by immunohistochemistry (CD20⁺ B cells; CD3⁺ T cells; CD163⁺ macrophages; CD56⁺ NK cells). DAPI, 4′,6-diamidino-2-phenylindole.