Biomarker responsiveness to the CRS score variation of patient 06 (grade 4 CRS). Longitudinal plots of the time rate of change of biomarker concentration (Δc/Δt) in black, the CRS score in light red, and the time rate of change of the CRS score (ΔCRS/Δt in light blue for IL-6 (A), MCP-1 (B), INF-γ (C), IL-10 (D), IL-8 (E), IL-2 and TNF-α (F), CRP (G), and ferritin (H). Typically, the time interval was set as Δt = 1 day. Δc was calculated by using the concentration at a given time point minus the concentration at 1 previous time point. The vertical dotted lines represent the time points at which an “onset” or an abrupt worsening of the CRS symptom was observed for the patient. ****P < .0001; ***P < .001; **P < .01; *P < .05; ns, P ≥ .05.