Expression of A20 and RNF138 in relationship to NF-κB activation in human lymphomas. (A) Representative images of IHC staining for RNF138, A20, and p-p65 Ser536 in lymphomas with and without MYD88^L265P. The images were taken from the same area for each target in individual lymphomas. Targets were stained with DAB as the chromogen (brown). The bar represents 10 μm. (B) Comparison of A20, RNF138, and p-p65 Ser536 expression between lymphomas with and without MYD88^L265P. (C) Correlation between the expression of A20 and RNF138 in lymphomas with and without MYD88^L265P. (D) Correlation between the expression of A20 and p-p65 Ser536 in lymphomas with and without MYD88^L265P. (E) Correlation between the expression of RNF138 and p-p65 Ser536 in lymphomas with and without MYD88^L265P. Pearson’s correlation coefficient tests provided the data in panels C-E. (F) The working model of MYD88, RNF138, and A20 in regulating physiological and oncogenic NF-κB activation. W, with; W/O, without.