Baseline mutational landscape and best overall clinical responses. Each column represents an individual patient, organized by best overall response. Genes (rows) are grouped by biological pathway. A blue box indicates the detection of a known or likely oncogenic variant in at least 1 sample type (peripheral blood and/or bone marrow). NA, not assessed; NE, not evaluable; PD, progressive disease; RTK, receptor tyrosine kinase; SD, stable disease.