Mutational landscape of GZL. (A) Oncoplot of the most recurrently mutated genes within the 50 GZL samples, with clinical annotation [(Ant_Med: anterior mediastinal involvement, pathological group (Path_Class)]. (B) Pairwise (Fisher’s exact test) comparison of the incidence of mutations within group 0, also know as GZL with a cHL morphology and expression of B-cell markers on all tumor cells, vs group 1 and group 2 GZL. The size of the bubble is inversely correlated to the P value. Full analysis and FDR testing are provided in supplemental Table 4. (C) Pairwise (Fisher’s exact test) comparison of the incidence of mutations within group 1, cHL-like GZL, vs group 2, LBCL-like GZL. The size of the bubble is inversely correlated to the P value. Full analysis and FDR testing are provided in supplemental Table 4. After FDR correction, for the 17 genes mutated in >20% of group 1 or group 2 cases, no mutations were significantly enriched in group 1 or 2. (D) GISTIC plot highlighting the main copy number variation in GZL. Data were obtained within the 21 exome cases and showed that the main gain/amp was in the 9p24.1 locus, with 81% of the cases affected.