Distinct effect of MEKi and anti-PD-1 on myeloid lesional cells and intralesional lymphoid cells. (A-F) FlowSOM analysis of representative lesion biopsy specimens from lung of BRAFV600E^CD11c mice in the indicated experimental groups. Green circle, myeloid compartment; blue circle, lymphoid compartment. (G) Representative immunohistochemistry images of infiltrating T cells (CD8⁺ and CD4⁺), and DCs (CD11b⁺ and CD11c⁺) in lungs of the different experimental groups. Bars represent 100 µm. (H) Quantification of lesion infiltrating CD8⁺ and CD4⁺ T cells in the indicated experimental groups. Data are the means ± SD (n = 9 mice per group); ***P < .001; ****P < .0001; ns, not significant (P > .05), by 1-way ANOVA with Tukey’s post hoc test.