PD1⁺TIM3⁺T cells display an exhausted transcriptomic signature. (A) Genes differentially expressed by PD1⁺TIM3⁺ and PD1⁻TIM3⁻ T-cell subsets. Genes are classified as specific to CD4⁺ T cells (red) or CD8⁺ T cells (green) or common to both subsets (blue). (B) List of top-10 genes differentially expressed by PD1⁺TIM3⁺ and PD1⁻TIM3⁻ T-cell subsets. (C) Upstream regulators for genes differentially expressed by PD1⁺TIM3⁺ and PD1⁻TIM3⁻ T-cell subsets.