The PD1⁺TIM3⁺T cell–exhausted phenotype. (A) Expression of CD45RA, CCR7, CD27, CD28, and CD127 by PD1⁺TIM3⁺, PD1⁺TIM3⁻, and PD1⁻TIM3⁻ CD8⁺ T-cell subsets (n = 10 DLBCL). (B) Expression of inhibitory, proliferation, and effector markers among CD8⁺ T-cell subsets. For each marker, the percentage was normalized and hierarchically clustered using Tmev software. *P ≤ .05, **P < .01, ***P < .001 by Wilcoxon parametric test.