Effects of drugs and drug reversibility in NK-cell lines in a 9-day assay. (A) Six NK-cell lines were treated with single drugs and combinations with indicated concentrations for 9 days. (B) Drug reversibility after 3-day drug perturbation in NK-cell lines. Cells were observed for 6 days after drug removal. Cell viabilities are normalized to positive and negative controls. Box indicates standard deviation; line, median; plus sign, mean; and bars, minimum and maximum of STAT3- and TP53-mutant cell lines (color labeled). Data are from 2 individual experiments performed at least in triplicate. Each dot represents a single assay point. **P < .01; ***P < .001 (Student t test). Dexa., dexamethasone; Idas., idasanutlin; ns, nonsignificant; Ruxo., ruxolitinib; S638., S63845; Tipi., tipifarnib.