Comparison of TTP assay vs short and extended time assays. Day when cells reached 10 million (one duplication) in the TTP assay correlated with DSS values from short-term assays (3 days) based on viability (A) and toxicity (B) readout, % inhibition values from extended 3-day treatment, 6-day recovery (C) and 9-day treatment assays (D), and ZIP synergy scores based on viability (E) and toxicity (F) readout. Red dots represent cell/treatment combinations that responded in the TTP assay; blue dots, treatments that did not respond; and gray cells, treatments that did not fall into either group. Cutoff for nonresponders was 10 days in the TTP assay and for the responders no growth at the end of the assay. Data are from Figures 1 to 4.